Comprehensive Vitality Packages
Wellness Support for the 21st Century
Markit Health conducts comprehensive analyses of superior supplements and products that help create wellness. Thousands of hours of research and hundreds of interviews with doctors and scientists have prompted our company
to offer these exclusive comprehensive vitality packs for health and vibrant aging. These products are not available in any health store or vitamin shop but are used by hundreds of clinics and health care professionals across the United States and abroad.

DNA360

Benefits | ac11 | OxyPhyte | The Science | FAQ | Label Facts

DNA360 Beneficial Effects

Enhance Natural DNA Repair
Protect DNA Integrity
Promote Energy & Wellness
Increase Collagen Production
Enhance Immune Functions
Quick Recovery from Daily Activities
Improve Quality of Sleep

Live Healthier, Longer by
Enhancing Natural DNA Repair

DNA360™ is a next level healthy aging supplement. With a myriad of products coming to market in the last 5 years based on scientific discoveries that protect DNA with targeted anti-oxidants, DNA360™ goes beyond protecting DNA to the point of actually enhancing your body’s ability to repair both single strand and double strand DNA damage. From conception through maturity, DNA repair is an essential biological process and the key to healthy aging.

The ac11® herbal extract found in DNA360™ is a breakthrough in phytonutrient science and simply enhances the body's natural DNA repair capacities. Each DNA360™ capsule provides 375 mg of ac11 and 100 mg of OxyPhyte Ultra Blend of Antioxidants.

DNA360™ assists the body's natural mechanisms for repairing DNA. The more efficient our body can repair DNA, the healthier we tend to be and the longer we tend to live. Accumulated DNA damage creates less healthy generations of new cells. This, in turn, precipitates reduced functional health and energy, while at the same time accelerating the aging process.

DNA360™ increases the effectiveness of other nutrients. This benefit is derived from ac11 found in DNA360™ creating more efficient cell to cell communication precipitated by optimal viscosity in the membrane of the cells in our body.

DNA360™ is also shown to support Apoptosis. Apoptosis is the death of cells that occurs as a normal and controlled part of an organism's growth or development. This is very important because, in multicellular organisms, cells that are no longer needed or are a threat to the organism need to be destroyed. DNA360™ has been researched using the thiol test and was found to significantly improve serum thiol values when taken orally. Thus, DNA360™ helps to clean up the accumulated DNA damage and the body, in its wisdom, will remove the most recent damage first. This helps to restore functional health and energy.

Among other effects, DNA360™ promotes certain DNA repair functions in the cell. Although the exact mechanisms of action are not completely understood, our scientists believe when the body is subjected to stress that may affect the integrity of the DNA, DNA360™ helps activate enzymes that are instrumental in the repair processes. In a series of peer reviewed scientific and clinical studies conducted by third party laboratories and university medical centers, we have shown that DNA360™ helps the body’s natural ability to repair DNA.

Backed by 10 U.S. and foreign patents, and with over 17 years of research and scores of published studies, ac11 demonstrably assists the body's natural mechanisms for repairing cellular DNA damage and promoting healing, energy production, immune function and wellness. Many people, including health care practitioners and professional athletes, use DNA360™ daily.

Additional Scientific Benefits of DNA360™  

The ac11 herbal extract found in DNA360™ helps stimulate natural production of collagen III, a form of collagen associated with soft, supple, youthful-looking skin. As we age, our cells gradually produce less collagen III than they did when we were young. However, laboratory research shows significant, measurable increases in collagen III production in adult skin cells treated with ac11

DNA360™ also helps to normalize the expression of NF-KB in the cells, thereby regulating cellular response to inflammation. NF-KB is a nuclear transcription factor that influences numerous gene-encoding proteins important in apoptosis (programmed cell death), inflammation and cellular growth. A normal expression of NF-KB minimizes the hazards of excessive oxidative stress. An over-expression of NF-KB triggers increased inflammation. 

Finally, in a human study, DNA360™ demonstrated a positive effect on lymphocytes, increasing their life span and, by implication, enhancing the body’s immune system.


The BENEFITS

Overall health starts with the health of your cells. Your cells replicate daily and the DNA inside cells is susceptible to damage simply from normal cell reproduction, stress, cellular metabolism, the environment, toxins and pollutants as well as a lack of quality nutrients. When DNA is damaged, the cells then replicate with errors, creating problems with your genetic code. The body experiences millions of DNA incidents per day that can contribute to damage. As we age, generations of these damaged cells diminish the function of your organ systems and tissues, reducing vitality, leading to aging and ultimately illness.

The results can be seen in many ways, including premature aging of the skin and loss of energy. Quite simply, "aging" is defined as the accumulation of unrepaired damage to our DNA over the years. As the cells in our bodies divide, unrepaired DNA damage is copied into the future generations of those cells. Left unrepaired, the collective damage leads in time to a degeneration of the body and accelerated aging.

Listed below are the benefits of repairing DNA with DNA360™ based on the science behind the active ingredient– ac11®

Overall Benefits:

Benefits for Anti-aging:

Benefits for Skin Health Supported by our Science:

Benefits for a healthier response to excessive inflammation:

Benefits for Physical Activities:

 

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ac11

The ac11® herbal extract found in DNA360™ History, Function, Efficacy & Safety

The Discovery of ac11

The method by which ac11 is formulated was discovered by Ronald W. Pero Ph.D., a widely published scientist, university professor emeritus and expert in the fields of human biochemistry and DNA research. Dr. Pero’s work involving ac11 was based on more than 30 years of research, including extensive field research on indigenous plant life in the Amazon region of South America.

ac11 is a novel proprietary extract of the herb Uncaria tomentosa, commonly known as Cat's Claw or Una de Gato. ac11 has a completely different mode of action than other cat's claw products. It offers a unique set of benefits for the immune system and DNA repair that are not available from other products.

While developing ac11 Dr. Ronald Pero identified that a previously unrecognized naturally occurring class of compounds known as carboxyl alkyl esters is the primary ingredient. Carboxyl alkyl esters (CAEs) are phospholipid-like compounds that can interact with the cholesterol/phospholipid ration in cell membranes and strongly influence the membrane integrity of cells. The CAEs as well as other esters present in ac11 have been shown to support immune system enhancement and natural DNA repair.

ac11 and The Science of Phytonutrients

The term "phyto" originates from a Greek word for “plant.”  Phytonutrients are the organic components of plants that promote health in humans and animals. Fruits and vegetables, grains, nuts, teas, etc. are all rich in phytonutrients.

A source of amazing phytonutrients unknown to exist elsewhere in the world is found in the rainforests of Brazil and Peru, often called the “living pharmacy” for the depth, variety and complexity of the plant and animal life forms that have developed there over many thousands of years, and for the breakthrough discoveries that researchers in biochemistry and pharmacological medicine continue to make in studying the wondrous ecosystem of this region.

Safe, all natural and water soluble ac11 is a patent-protected, bioactive rainforest plant extract that helps the body to repair environmental stress-related damage to DNA, and slow down the process of aging. ac11 is the perfect joining of the rainforest’s secrets with the miracle of today’s advancements in phytonutrient science.

DNA Care & ac11

ac11 derives from Uncaria tomentosa, a plant indigenous to the rainforest. We create ac11 using a patented, wholly proprietary “aqueous hot water extraction” and purification process standardized to a minimum of 8% Carboxy Alkyl Esters (CAE) concentration. 

CAEs are the complex molecular chains that form the primary active components of ac11  –They are responsible for approximately 90% of the biological activity in ac11 relating to DNA repair and immune enhancement.

Although the exact mechanisms of action are not all completely understood, our scientists believe that when the body is subjected to stress that may affect the integrity of the DNA (overexposure to the sun for example), ac11 helps activate enzymes that are instrumental in the repair processes. In a series of peer reviewed scientific and clinical studies conducted by third party laboratories and university medical centers, we have shown that ac11 helps the body’s natural ability to repair DNA.

ac11 studies moreover show that the CAEs unique to our product not only enhance significantly the body’s natural ability to repair damaged DNA, but also measurably improve natural collagen III production in the skin. 

Collagen III is a form of collagen associated with soft, supple, youthful-looking skin. As we age, our cells gradually produce less collagen III than they did when we were young. However, laboratory research shows significant, measurable increases in collagen III production in adult skin cells treated with ac11
ac11 also helps to normalize the expression of NF-KB in the cells, thereby regulating cellular response to inflammation. NF-KB is a nuclear transcription factor that influences numerous gene-encoding proteins important in apoptosis (programmed cell death), inflammation and cellular growth. A normal expression of NF-KB minimizes the hazards of excessive oxidative stress. An over-expression of NF-KB triggers increased inflammation.

In a human study, ac11 demonstrated a positive effect on lymphocytes, increasing their life span and, by implication, enhancing the body’s immune system.
ac11 differs from all other Uncaria tomentosa products, some of which are sold under the common name “cat’s claw,” in that its molecular composition is distinct by virtue of the Optigenex patented process. ac11 is standardized, pure, water-soluble and micro-filtered to contain only low weight molecules (<10,000 Daltons). ac11 is relatively alkaloid free (<0.05%) and is the only product available anywhere containing a patented class of CAE actives shown by extensive research to have healthy aging and natural DNA enhancement properties. No other Uncaria tomentosa product can make these claims. ac11 moreover has been studied for efficacy and safety for over ten years.

ac11 Efficacy & Safety

ac11 is backed by an extensive Efficacy and Safety profile. Pure, bioactive ac11 is the only known plant extract in the world shown by research studies to enhance our natural DNA repair processes. In fact, few other nutraceutical or cosmeceutical plant extract ingredients have been subjected to as much rigorous scientific study as has ac11.

ac11  strictly conforms to the unique specifications set by our manufacturing methods and standardization claims. We perform all of the standard industry-accepted tests to ensure that our product meets requirements for sale in the United States and other centers of commerce throughout the world. To make ac11  we engage the services of Centroflora Group in Botucatu, Brazil, a U.S. Department of Agriculture approved and ISO 9002 certified facility operated in accordance with FDA (U.S. Food and Drug Administration) regulations and GMP (Good Manufacturing Practices) standards, and one of the finest facilities in the world for the production of phytotherapic extracts. Using proprietary equipment conceived and developed by our company, ac11  is manufactured at Centroflora under state-of-the-art conditions and we warrant our product’s conformance to its specifications as well as to applicable governmental regulations.
ac11’s purity is due to the clean, contaminant and chemical toxin-free rainforest environment in which the plant is harvested and processed, as well as the patented Optigenex molecular sieving (filtration) process. By contrast, mild toxicity with long term use often is observable in other “Uncaria” products, especially the water-insoluble, alkaloid based extracts.

The ac11 “Rainforest Connection”

ac11  is derived naturally from Uncaria tomentosa, a vine that grows wild in the Amazon rainforest. We harvest the vine in an ethical manner under the authority of the Brazilian Institute of Environment and Renewable Natural Resources (IBAMA). This ensures future maintenance of a natural balance in the rainforest. Authorization is granted through an ongoing sustainable management project directed by the government and based upon existing local herb availability whereby the amount of inner bark approved for harvesting is set. The harvest is taken (cut) at a point on the plant approximately three feet above the ground; the plant is then capped to ensure integrity of the root structure and rapid regeneration of the vine. Additionally, new saplings of the Uncaria tomentosa vine are planted in a precise manner to ensure the continued viability in the harvesting area.  Optigenex moreover works in cooperation with the Floravida Institutes (Brazil) guidelines for biodiversity conservation, environmental education and local community social inclusion.

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OxyPhyte® Ultra Blend

The overall effectiveness of DNA360™ is not just limited to the ground-breaking effects of ac11, we have also added 100 mg of superior anti-oxidants.

OxyPhyte® Ultra is a proprietary, whole-food-derived antioxidant blend derived from fruits and teas. Our manufacturer is the only manufacturer to test ORAC value and standardize antioxidant ingredients and blends to efficacious marker compounds—not just once, but every single batch.

ORAC stands for Oxygen Radical Absorbance Capacity. It's a lab test that attempts to quantify the "total antioxidant capacity" (TAC) of a food by placing a sample of the food in a test tube, along with certain molecules that generate free radical activity and certain other molecules that are vulnerable to oxidation.

OxyPhyte® Ultra Blend consists of Apple Fruit Extract (75% polyphenols), White Tea Leaf Extract (90% polyphenols) and Rosemary Leaf Extract (9% rosmarinic acid)

Cellular Uptake & Activity

The Cell-based Antioxidant protection in Erythrocytes (CAP-e) is an ex-vivo assay that confirms the cellular uptake potential of an antioxidant, which provides a piece of the antioxidant puzzle not predicted by ORAC.

CAP-e results for OxyPhyte Antioxidants show that each ingredient has cellar bioavailability and supports healthy redox reactions within cells.

Bioavailability

Our OxyPhyte Ultra Blend has confirmed bioavailability with human volunteers.

In this preliminary study: The baseline ORAC level of blood serum was measured in subjects prior to ingesting 400 mg of OxyPhyte Ultra (approximately 3600 ORAC units). After consumption, blood serum ORAC was measured after 30 minutes, then again after one hour.

Peak blood ORAC levels compared to baseline Increased up to 32% (average was 12%), providing evidence that OxyPhyte is absorbed into the blood and supports the antioxidant capacity of blood plasma.

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The SCIENCE

Backed by 10 U.S. and foreign patents, and with over 17 years of research and scores of published studies, ac11® demonstrably assists the body's natural mechanisms for assisting in the repair of cellular DNA damage and promoting healing, energy production, immune function and wellness. Many people, including health care practitioners use ac11 daily.

  • Chemotherapy Induced Leucopenia, Animal Study, Phytomedicine, 2000
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  • Enhanced DNA Repair and Immune Function, Animal Study, Ethnopharmacology, 2000
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  • Enhanced Response to Vaccine, Human Study, Phytomedicine, 2001
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  • Enhanced DNA Repair, Human Study, Phytomedicine, 2001
    Download PDF →
  • AC-11® in Combination with Synergistic Nutritional Supplements, Human Study, Anti-Aging Medicine, 2002
    Download PDF →
  • Inhibition of Tumor Cell Proliferation, Animal Study, International Immunopharmacology, 2003
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  • Prolonged Lymphocyte Survival, Animal Study, Phytomedicine, 2003
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  • AGI Dermatics Topical Study, 2004 Unpublished
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  • DNA Repair and Weight Loss, Human Study, Phytomedicine, 2005
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  • Estee Lauder-Sponsored Topical Study, Phytotherapy Research, 2006
    Download PDF →
  • DNA Repair Adjuvants, Skin & Aging, 2006
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  • Botanical Extract Protects Against UV, Dermatology Times, 2006
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  • Review of DNA Repair Adjuvants and Selected Natural Anti-Oxidants, Dermatology Online Journal, 2007
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  • Interview with Dr. Noah Scheinfeld, Whole Foods, 2008
    Download PDF →
  • Laboratoire BIO-EC (France) Summary of Study → Skin Health and Benefits, 2008 Unpublished
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  • C-Med - 100 → a novel, natural compound that averts inflammation and protects natural immunity through DNA
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  • DNA Repair. Maintaining performance and appearance at any age.
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Journal Articles

  • An active ingredient of Cat's claw water extracts → Identification and efficacy of quinic acid.
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  • Anti-inflamatory activity of two different extracts of Uncaria Tomentosa (Rubiaceae)
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  • Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria Tomentosa
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  • Quinic acid is a biologically active component of the Uncaria Tomentosa extract C-MED 100
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Reports

  • Activar Day Cream → Repeated insult patch
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  • Activar Eye Cream → Repeated insult patch
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  • Activar Eye Cream → The hen's nest egg test-utilizing the chorioallantoic membrane (HET-CAM)
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  • Activar Night Cream → Repeated insult patch test
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  • Salmonella typhimurium reverse mutation assay → Ames test
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Related Articles

  • Antioxidant metabolism induced by quinic acid → Increased urinary excretion of tryptophan and nicotinamide.
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  • DNA repair enhancedment by a combined supplement of carotenoids, nicotinamide, and zinc.
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  • Health consequences of catabolic synthesis of hippuric acid in humans.
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  • In vivo treatment of humans with quinic acid enhances DNA repair and reduces the influence of lifestyle.
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  • Low serum thiol levels predict shorter times-to-death among HIV-infected injecting drug users.
    Download PDF →
  • Markers of DNA repair and susceptibility to cancer in humans → An epidemiologic review.
    Download PDF →
  • Metabolic syndrome, hormones, and maintenance of T cells during aging.
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  • Quantitative analytical method development for the assessment of bioactive quinic acid-type esters and free quinic acid in dietary supplements.
    Download PDF →
  • Reduced level of serum thiols in patients with a diagnosis of active disease.
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  • Serum thiols as a surrogate estimate of DNA repair correlates to mammalian life span.
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  • Surrogate indication of DNA repair in serum after long term chiropractic intervention-A retrospective study.
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  • The role of DNA damage repair in aging of adult stem cells.
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  • Cat's claw.
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  • Efficacy and safety of ac-11
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  • Historical development of Uncaria preparations and their related bioactive components.
    Download PDF →
  • The immunomodulatory properties of C-MED 100 and extract of the plant Uncaria Tomentosa.
    Download PDF →

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Frequently Asked Questions (FAQ’s)

1.  What is ac11® (The active ingredient found in DNA360™)?

ac11 is a patented, all natural, water soluble extract of a tropical plant known as Uncaria tomentosa.  ac11 is the registered trademark name under which ac11 also a registered trademark, formerly was known. The method by which ac11 is formulated is wholly proprietary to Optigenex.  From the raw material of the plant’s inner bark, our product is created through an aqueous hot water extraction process. It is then micro-filtered to remove all alkaloids (leaving less than 0.05%) and other high molecular weight compounds from the primary extract, and also to concentrate and standardize the Carboxy Alkyl Esters (CAEs) – the biologically active principal components in ac11 – Pure, bioactive ac11 is the only known plant extract in the world shown by research studies to enhance our natural DNA repair processes.

2.  What is DNA?

DNA is deoxyribonucleic acid. It is a double-stranded helix that carries our individual genetic codes.

3.  How important is DNA to our health?

DNA is the most important molecule in the body, and damage to this amazing molecule is the ultimate basis for aging and disease. It is the accumulation of damage to our DNA that accelerates the aging and disease process.

4.  What is Natural DNA Repair?

Natural DNA repair involves a series of enzymatic processes that remove lesions (damage) in our DNA caused by oxidative and non-oxidative stress, thus preserving genetic integrity and normal cell function. These processes begin at conception and end with death and occur several thousand times a day in the body. The more efficient our natural DNA repair processes are, the longer and healthier our lives can be.

5. What are Carboxy Alkyl Esters (CAEs)?

Carboxy Alkyl Esters (CAEs) are complex molecular chains that have been identified as the primary active components in ac11  –They are responsible for approximately 90% of the biological activity in ac11 relating to DNA repair and immune enhancement.

6. How does DNA repair affect our immune system?

Our immune cells, some of which live long lives, circulate through the body defending it in numerous ways. If the DNA in our immune cells is damaged by oxidative or non-oxidative stress, the cells cannot divide or else may divide in a manner impairing their function. Immune response as a result may be suppressed and disease may be more likely to take hold. This phenomenon is at the core of many age-related diseases.

 7. Doesn’t our genetic inheritance pre-determine our life spans and the gene-related diseases we may encounter in life?

Not necessarily. Our genetic inheritance does not guarantee that we will age exactly the same way as our family members, nor does it ensure that we must succumb to the same gene-related diseases. We can avoid certain environmental and dietary pitfalls that are known to accelerate aging and that may promote or trigger the onset of certain genetically or environmentally-based diseases. For example, we can avoid too much sun, cigarettes, excessive alcohol consumption, and unnecessary exposure to environmental pollutants, as well as try to regulate daily stress in our lives.  We can also choose an antioxidant rich diet, supplementing at the same time our nutritional intakes in smart ways to minimize cellular damage and improve the repair mechanisms built in to our cells. While antioxidants and foods rich in antioxidants can reduce the cellular and DNA damage that occurs daily, they cannot repair damage that occurs. ac11 is the first known natural product shown to improve DNA repair.

8. How does ac11 work?

Among other effects, ac11 promotes certain DNA repair functions in the cell. Although the exact mechanisms of action are not all completely understood, our scientists believe when the body is subjected to stress that may affect the integrity of the DNA (overexposure to the sun for example), ac11 helps activate enzymes that are instrumental in the repair processes. In a series of peer reviewed scientific and clinical studies conducted by third party laboratories and university medical centers, we have shown that ac11 helps the body’s natural ability to repair DNA.  Links to a number of articles analyzing the science behind ac11 may be found at ac11 Science.

9. Does ac11 help the body in any other ways?

Yes. ac11 helps stimulate natural production of collagen III, a form of collagen associated with soft, supple, youthful-looking skin.  As we age, our cells gradually produce less collagen III than they did when we were young.  However, laboratory research shows significant, measurable increases in collagen III production in adult skin cells treated with ac11 | ac11 also helps to normalize the expression of NF-KB in the cells, thereby regulating cellular response to inflammation. NF-KB is a nuclear transcription factor that influences numerous gene-encoding proteins important in apoptosis (programmed cell death), inflammation and cellular growth. A normal expression of NF-KB minimizes the hazards of excessive oxidative stress. An over-expression of NF-KB triggers increased inflammation. Finally, in a human study, ac11 demonstrated a positive effect on lymphocytes, increasing their life span and, by implication, enhancing the body’s immune system. Links to articles on some of these subjects may be found on ac11 Science.

10. What makes ac11 different from other Uncaria tomentosa products?

ac11 differs from all other Uncaria tomentosa products, some of which are sold under the common name “cat’s claw,” in that its molecular composition is unique by virtue of the Optigenex patented process.  ac11 is standardized, pure, completely water-soluble and micro-filtered to contain only low weight molecules (< 10,000 Daltons). ac11 is relatively alkaloid free (<0.05%) and is the only product available anywhere containing a patented class of CAE actives shown by extensive research to have healthy aging and natural DNA repair enhancement properties.  No other Uncaria tomentosa product can make these claims. ac11 moreover has been studied for efficacy and safety for over ten years.

11. How is the manufacture of ac11 quality controlled?

ac11 as sold strictly conforms to the unique specifications set by our manufacturing methods and standardization claims. We perform all of the standard industry-accepted tests to ensure that our product meets requirements for sale in the United States and other centers of commerce throughout the world. To make ac11 we engage the services of Centroflora Group in Botucatu, Brazil, a U.S. Department of Agriculture approved and ISO 9002 certified facility operated in accordance with FDA (U.S. Food and Drug Administration) regulations and GMP (Good Manufacturing Practices) standards, and one of the finest facilities in the world for the production of phytotherapic extracts.  Using proprietary equipment conceived and developed by our company, ac11 is manufactured by Centroflora under state-of-the-art conditions and we warrant our product’s conformance to its specifications as well as to applicable governmental regulations.  Interested parties may contact Optigenex in writing to request further information.

12. Is there any toxicity shown with ac11?

No. The LD-50 of ac11 is greater than 8,000mg/kilogram. The recommended daily dosage of ac11 in “stand alone” form is between 350 and 700mg (250 mg. minimum in products combining ac11 with other active ingredients) for a person weighing 150-200 lbs. (70-90 kilograms). ac11 purity is due to the clean, contaminant and chemical toxin-free rainforest environment in which the plant is harvested and processed, as well as the patented Optigenex molecular sieving (filtration) process. By contrast, mild toxicity with long term use often is observable in other “Uncaria” products, especially the water-insoluble, alkaloid based extracts. For more detailed information, interested parties may contact Optigenex in writing to request the company’s ac11 “Efficacy and Safety” profile (study report).

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LABEL FACTS



 

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These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any pharmaceutical product without first consulting your prescribing physician. Resale of Markit Health, LLC products without written permission is strictly prohibited. Prices Are Subject to Change. Updated 2/20/18.